Science:
This word is only funny to our friends that are anti-vaxxers or those that believe climate change is a hoax. Once you get them warmed up talking about science keep the merriment going discussing other wacky concepts like Meteorology, Microbiology and Physiology, almost any “ology” related word. You’ll keep them in hysterics…literally.
(Word of caution: Don’t mention Scientology).